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Magnogene 45 Coated Tablets

Contains magnesium as an active substance. It belongs to the group of medicines called "mineral supplements".

It is used to prevent magnesium deprived states due to diets poor in vegetables, whole grains and legumes that manifest thee with weakness and muscle cramps that may occur in adults and children over 12 years of age.

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1. What is MAGNOGENE and what is it used for?

Contains magnesium as an active ingredient. It belongs to a group of medicines called “mineral supplements”.


It is used for the prevention of magnesium deficiency states due to diets poor in vegetables, whole grains and legumes that manifest with weakness and muscle cramps that may occur in adults and children over 12 years of age.



Do not take Magnogene if:


  • are allergic (hypersensitive) to magnesium salts or any of the other ingredients of Magnogene.
  • suffer from a kidney disorder.
  • suffers or has suffered from heart diseases such as heart block or has been diagnosed with ischemic heart disease (angina pectoris, myocardial infarction, ... which is due to a lack of blood supply to the heart).
  • you suffer or have suffered from a diabetic coma (loss of consciousness due to excessively high or low blood sugar).
  • You have been diagnosed with myasthenia gravis (autoimmune neuromuscular disease).
  • suffer from chronic diarrhea or have been diagnosed with ulcerative colitis (inflammatory bowel disease).
  • you have had an ileostomy (intervention in the intestine).
  • has symptoms of appendicitis: abdominal pain (pain around the navel) that increases in intensity and moves towards the lower right part of the abdomen as the process progresses. This pain may be accompanied by loss of appetite (decreased desire to eat), nausea, vomiting, and a low fever.


Take special care with Magnogene:


  • Continued use of this medicine can cause hypermagnesemia (high level of magnesium in the blood) characterized by nausea, vomiting, respiratory depression (weak breathing), and Central Nervous System depression (symptoms can range from drowsiness to coma). hyperreflexia (exaggeration of reflexes), muscle weakness and certain cardiovascular effects such as low blood pressure, decreased heartbeat and cardiac arrest.
  • Taking this medicine on an empty stomach can cause diarrhea.
  • Patients with kidney disease should consult with the doctor before taking this medicine.


Use in children:

Do not administer to children under 12 years except medical criteria.


Use in over 65s:


In patients over 65 years of age who suffer a decrease in kidney function, the dose and frequency of administration of magnesium salts should be modified by the doctor according to the degree of this decrease in renal function.


Use of other medications:

Please inform your doctor or pharmacist if you are using or have recently used any other medicines, even those obtained without a prescription.


Interactions may occur with the following medications:


Azole antifungal agents (for fungi) such as itraconazole, fluconazole.


Antibiotics such as tetracyclines (doxycycline, minocycline, oxytetracycline, tetracycline) and quinolones (ciprofloxacin, levofloxacin, norfloxacin, ofloxacin), the effectiveness of the antibiotic may be reduced.


Bisphosphonates (medicines used to treat osteoporosis).


Delavirdine, is an antiretroviral agent, used to treat HIV / AIDS infection.


Digitalis, are used for the treatment of congestive heart failure. The main digitalis is Digoxin.

Sodium polystyrene sulfonate, used to treat hyperkalemia, metabolic alkalosis may occur.


Quinidine, which is used to treat heart rhythm disturbances.


Note that these instructions can also apply to medications that have been taken before or can be taken afterwards, so in general, at least 2 hours should be allowed to elapse between the administration of Magnogene and any other oral medication, and which can decrease or increase the absorption of other drugs.


Taking magnesium with food and drink

Excessive and prolonged consumption of products containing magnesium and calcium can cause high concentrations of calcium in the blood. In these situations, the intake of calcium and foods rich in calcium such as dairy should be controlled.


Alcohol and glucose increase the excretion of magnesium.


Pregnancy and breastfeeding:

Consult your doctor or pharmacist before taking any medicine.


It is recommended to cover the needs of magnesium with a diet rich in vegetables, whole grains to prevent the consequences of magnesium deficiency in pregnancy.


Important for women:

If you are pregnant or think you might be, consult your doctor before taking this medicine. The use of medications during pregnancy can be dangerous for the embryo or the fetus, and should be monitored by your doctor.



Consult your doctor or pharmacist before taking any medicine.


No problems have been reported in nursing children whose mothers take Magnogene tablets at the recommended doses.


Driving and using machines:

Effects on the ability to drive or use tools and machines are not to be expected.


Important information about some of the ingredients of Magnogene

This medicine contains lactose. If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this medicine.


This medicine contains sucrose. If your doctor has told you that you have an intolerance to some sugars, contact him before taking this medicine.



Follow these instructions exactly unless your doctor has given you different directions. Ask your doctor or pharmacist if you have doubts.


This medicine is administered orally.


Do not take on an empty stomach, as it can cause diarrhea.

Each coated tablet should be swallowed whole, with water or other liquid, without breaking or chewing. The recommended average dose for adults and children over 12 years of age is 2 coated tablets, 2 times a day after meals, swallowed with some liquid (212 mg of magnesium a day).


Over 65, children under 12 and patients with kidney disease should consult a doctor


If symptoms worsen or do not improve in 15 days, you should see your doctor.


If you take more Magnogene than you should:


Consult your doctor or pharmacist immediately.

The symptoms of hypermagnesemia are: hot flashes, slow heartbeat, central nervous system depression, muscle weakness, fatigue, drowsiness or hyperexcitability, nausea, hypotension, confusion, respiratory depression, arrhythmias, coma, and cardiac arrest.

Hypermuscular blockage associated with hypermagnesemia is reversible by administering calcium salts.

If kidney function is normal, fluids should be given to remove magnesium from the body. If kidney function is impaired or hypermagnesemia is severe, dialysis should be used.


In case of overdose or accidental ingestion, go immediately to a medical center or call the Toxicology Information Service, tel .: 91-5620420, indicating the medicine and the amount ingested.


If you forget to take Magnogene

Do not take a double dose to make up for a forgotten dose. Take your dose as soon as you remember and continue treatment as before.


If you have any questions on the use of this product, ask your doctor or pharmacist.


4. Possible side effects

Like all medicines, Magnogene can cause side effects, although not everyone gets them.


During the period of use of this medicine, the following side effects have been reported, the frequency of which could not be accurately established. The most characteristic have been gastrointestinal disorders such as diarrhea and vomiting and, less frequently, an increase in magnesium in the blood, which is manifested by: drowsiness, double vision, dizziness, muscle weakness, decrease in blood pressure.


If you consider that any of the side effects you suffer is serious or if you notice any side effect not mentioned in this leaflet, inform your doctor or pharmacist.


5. How to store MAGNOGENE

Keep out of the reach and sight of children.


It does not require any special storage conditions.


Do not use this medicine after the expiry date which is stated on the carton after "EXP:". The expiration date is the last day of the month indicated.


Medicines must not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of unneeded medicine and containers. This way you will help to protect the environment.



Composition of Magnogene:


Each coated tablet contains 53 mg of magnesium provided by 125.06 mg of magnesium hydroxide; 7.17 mg of magnesium bromide and 0.34 mg of magnesium fluoride.


The other ingredients (excipients) are: sodium chloride, sodium iodide, lactose, corn starch, povidone, macrogol 4000/10000, talc, magnesium stearate, 30% dispersion of methacrylic acid ethyl acrylate copolymer (1: 1), calcium carbonate, sucrose, acacia, titanium dioxide (E-171), macrogol 6000.


What the product looks like and contents of the pack

Magnogene is a medicine in the form of coated tablets for oral use, which is presented in a container of 45 tablets.


Holder of the marketing authorization and responsible for manufacturing



Av. Camí Reial 51-57

08184 Palau-solità i Plegamans

(Barcelona, Spain)


Responsible for manufacturing


Avenida de Madrid, 82

28802 - Alcalá de Henares

(Madrid Spain)





Av. Camí Reial, 51-57

08184 Palau-solità i Plegamans

(Barcelona, Spain)




This leaflet was revised in December 2010

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